MOTS-c specifications and research profile
Specifications summary
| Designation | Mitochondrial-derived 16-amino-acid peptide |
|---|---|
| Also known as | Mitochondrial open reading frame of 12S rRNA-c |
| Sequence / composition | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Strength | 10mg |
| Presentation | Powder vial |
| Purity | 99%+ HPLC |
| Storage | Store refrigerated at 2-8 C, protected from light. |
| COA | View MOTS-c 10mg COA - 5 June 2026 |
Description and research context
MOTS-c is a mitochondrial-derived peptide encoded by a short open reading frame within the mitochondrial 12S rRNA region. It is used as a molecular reference for studying signalling between mitochondrial genetic information and nuclear or cytosolic responses.
The original discovery work linked MOTS-c exposure in cellular and mouse models with folate-cycle and purine-biosynthesis changes followed by AMPK activation. These observations are preclinical and depend on the model, concentration and exposure interval.
Applications in research
- Mitochondrial-derived peptide signalling studies
- AMPK, folate-cycle and purine-biosynthesis pathway assays
- Mitochondrial-to-nuclear communication and stress-response models
Precautions and interpretation
For controlled laboratory research only. Not for human or veterinary use. The cited findings come from specific biochemical, cellular, structural or preclinical models and must not be treated as usage guidance or evidence of a defined outcome outside those models.
Research references
MOTS-c research record
Clear product, batch, storage, dispatch and document information for this powder vial.
Research context
MOTS-c is listed as a research-use peptide reference for laboratory work involving mitochondrial signalling models and controlled peptide comparison workflows.
Lead time
This listing may be displayed while out of stock with an estimated two-week lead time before fulfilment can be confirmed.
Use restriction
For laboratory research use only. Not for human or veterinary consumption. No use instructions or therapeutic guidance is provided.