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MOTS-c research profile
What is being studied?
MOTS-c is a mitochondrial-derived peptide encoded by a short open reading frame within the mitochondrial 12S rRNA region. It is used as a molecular reference for studying signalling between mitochondrial genetic information and nuclear or cytosolic responses.
The original discovery work linked MOTS-c exposure in cellular and mouse models with folate-cycle and purine-biosynthesis changes followed by AMPK activation. These observations are preclinical and depend on the model, concentration and exposure interval.
Research areas
- Mitochondrial-derived peptide signalling studies
- AMPK, folate-cycle and purine-biosynthesis pathway assays
- Mitochondrial-to-nuclear communication and stress-response models
Selected studies
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Cell and animal study · 2015The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis ↗
Investigated mitochondrial peptide signalling and AMPK-associated pathways in cells and mice.
How to read this research
These papers study defined compounds in specific experimental systems or clinical trials. They do not test or certify this product, its batch or its prepared presentation. Component and related-peptide studies do not establish the effects of a finished blend. Findings are research context, not evidence of safety or suitability for personal use. For laboratory research only; no treatment, dosing or use advice is provided.
MOTS-c research record
Molecular identity and stated sequence or composition, alongside the batch, storage, dispatch and document record for this powder vial.
Molecular identity
Mitochondrial-derived 16-amino-acid peptide
Sequence / composition
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Product record
The listing identifies the presentation, specification, storage record, dispatch status, and batch-document availability for the relevant product or batch.
Use restriction
For laboratory research use only. Not for human or veterinary consumption. No use instructions or therapeutic guidance is provided.