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Retatrutide research profile
What is being studied?
Retatrutide (LY3437943) is an engineered single peptide with agonist activity at the glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and glucagon receptors. This three-receptor profile makes it a reference compound for multi-agonist receptor pharmacology.
Structural and signalling studies have examined how retatrutide is recognised by GIPR, GLP-1R and GCGR in receptor-Gs complexes. Laboratory applications include receptor binding, cAMP-response and pathway-bias comparisons; results must be interpreted within the tested model.
Research areas
- Comparative GIPR, GLP-1R and GCGR binding and activation assays
- cAMP and Gs-coupled signalling measurements
- Structural comparison of single-, dual- and triple-agonist peptide designs
Selected studies
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Structural and cell study · 2024Structural insights into retatrutide triple agonism ↗
Examined retatrutide recognition by three receptor complexes and receptor signalling assays.
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Human phase 2 trial · 2023Triple-hormone-receptor agonist retatrutide ↗
A randomised trial of investigational retatrutide in adults with obesity; it did not test this catalogue product.
How to read this research
These papers study defined compounds in specific experimental systems or clinical trials. They do not test or certify this product, its batch or its prepared presentation. Component and related-peptide studies do not establish the effects of a finished blend. Findings are research context, not evidence of safety or suitability for personal use. For laboratory research only; no treatment, dosing or use advice is provided.
Retatrutide research record
Molecular identity and stated sequence or composition, alongside the batch, storage, dispatch and document record for this powder vial.
Molecular identity
Single-peptide triple receptor agonist
Sequence / composition
Engineered peptide agonist of GIPR, GLP-1R and GCGR
Product record
The listing identifies the presentation, specification, storage record, dispatch status, and batch-document availability for the relevant product or batch.
Use restriction
For laboratory research use only. Not for human or veterinary consumption. No use instructions or therapeutic guidance is provided.